专家风采

刘鉴峰

刘鉴峰,男,研究员,博士生导师,国家优秀青年科学基金获得者,天津青年科技奖获得者,“协和新星”,中国医学科学院医学与健康科技创新工程协同创新团队项目首席专家,放射医学研究所核医学应用研究室主任。2002年本科毕业于烟台大学,先后于2005年和2011年获得南开大学生命科学学院硕士和博士学位。天津市医学会核医学分会第七届常委,中国核学会同位素分会第五、六届理事会理事,中华医学会核医学分会第九、十届委员会实验核医学学组成员,天津市核学会第四届理事会理事,天津市药理学会第六届理事会理事,天津市医学影像技术研究会核医学专业委员会委员,中华医学会放射医学与防护学分会第九届委员会青年委员,天津市药理学会首届青年药理学工作者委员会委员,中国生物物理学会辐射与环境专业委员会青年委员,国家自然科学基金评审专家。第一完成人获得天津市科技进步二等奖。近五年来发表SCI收录论文60余篇(累计影响因子>300),单篇平均影响因子>6,SCI引用>700。申请专利四项,其中授权专利两项。

研究方向

纳米医学、影像医学与核医学。具体开展的研究内容:

1、纳米药物载体

2、多模态分子影像探针

       3、药物的放射性核素标记及临床前药代动力学研究

承担项目:

作为项目负责人承担国家级省部级项目十余项,总经费两千五百余万。

1、国家优秀青年科学基金项目:“纳米医用材料”(No. 81722026),2018.1~2020.12项目负责人

2、  中国医学科学院医学与健康科技创新工程协同创新团队项目:“放射性核素标记药物及临床前药代动力学关键技术研发”(No. 2016-12M-3-022),2016.9~2020.12  首席专家

3、  天津市新药创制科技重大专项:“低能放射性核素标记及药物临床前药代动力学关键技术平台建设”,(No. 16ZXXYSY00040),2016.10~2018.9   项目负责人

4、  国家自然科学基金面上项目:“智能化双靶向肿瘤光学/核素/MRI多模态分子探针的合成及其性能研究”(No. 81471727),2015.1~2018.12  项目负责人 

5、  国家自然科学基金面上项目:“显像与放射免疫治疗用PAMAM多功能纳米材料的构建与性能研究”(No. 81171371),2012.1~2015.12 项目负责人

6、  天津市自然科学基金重点项目:“新型肿瘤多模态纳米分子探针的制备及其功能研究”(No. 13JCZDJC28100),2013.4~2016.3 项目负责人

7、  中国医学科学院“协和新星人才支持计划”,2014.11~2018.10项目负责人

8、  国家自然科学基金青年项目:“新型纳米抗肿瘤药物靶向载体的制备及其功能研究”(No. 30700178),  2008.1~2010.12 项目负责人

 

发表文章:

近年来发表SCI论文60余篇,部分第一/通讯作者文章:

1.       Cuihong Yang, Chunhua Ren, Jie Zhou, Jinjian Liu, Yumin Zhang, Fan Huang, Dan Ding, Bing Xu*,Jianfeng Liu*. Dual fluorescent- and isotopic-labelled self-assembling vancomycin for in vivo imaging of bacterial infections. Angewandte Chemie-International Edition. 2017 Feb 20;56(9):2356-2360  IF: 11.709

2.       Yanbin Cai, Haosheng Shen, Jie Zhan, Mingliang Lin, Liuhan Dai, Chunhua Ren, Yang Shi, Jianfeng Liu*, Jie Gao*, Zhimou Yang*. Supramolecular “Trojan Horse” for nuclear delivery of dual anticancer drugs. Journal of the American Chemical Society. 2017 Feb 13;139(8):2876-2879.  IF: 13.038

3.       Pingsheng Huang, Huijuan Song, Yumin Zhang, Jinjian Liu, Zhen Cheng, Xingjie Liang, Weiwei Wang*, Deling Kong, Jianfeng Liu*. FRET-enabled monitoring of the thermosensitive nanoscale assembly of polymeric micelles into macroscale hydrogel and sequential cognate micelles release. Biomaterials · July 2017. DOI: 10.1016/j.biomaterials.2017.07.012  IF: 8.402

4.       Fan Huang, Yang Gao, Yumin Zhang, Tangjian Cheng, Hanlin Ou, Lijun Yang, Jinjian Liu*, Linqi Shi*, Jianfeng Liu*. Silver-Decorated Polymeric Micelles Combined with Curcumin for Enhanced Antibacterial Activity. ACS Applied Materials & Interfaces. 2017 May 8; 9(20): 16880-16889  IF:7.145

5.       Liping Chu#, Honglin Gao#, Tangjian Cheng, Yumin Zhang, Jinjian Liu, Fan Huang, Cuihong Yang*, Linqi Shi*, Jianfeng Liu*. A charge-adaptive nanosystem for prolonged and enhanced in vivo antibiotics delivery. Chemical Communications. 2016 Apr 14; 52(37):6265-8.      IF:6.567

6.       Tangjian Cheng, Jinjian Liu, Jie Ren, Fan Huang, Hanlin Ou, Yuxun Ding, Yumin Zhang, Rujiang Ma, Yingli An, Jianfeng Liu*, Linqi Shi*. Green tea catechin-based complex micelles combined with doxorubicin to overcome cardiotoxicity and multidrug resistance. Theranostics. 2016; 6(9): 1277-92. IF:8.854

7.       Jinjian Liu#, Qian Liu#, Cuihong Yang, Yu Sun, Yumin Zhang, Pingsheng Huang, Junhui Zhou, Qiang Liu, Liping Chu, Fan Huang, Liandong Deng*, Anjie Dong, Jianfeng Liu*. cRGD modified benzimidazole-based pH-responsive nanoparticles for enhanced tumor targeted doxorubicin delivery. ACS Applied Materials & Interfaces. 2016 May 4;8(17):10726-36.   IF:7.145

8.       Yumin Zhang#, Cuihong Yang#, Weiwei Wang, Jinjian Liu, Qiang Liu, Fan Huang, Liping Chu, Honglin Gao, Chen Li, Deling Kong, Qian Liu*, Jianfeng Liu*. Co-delivery of doxorubicin and curcumin by pH-sensitive prodrug nanoparticle for combination therapy of cancer. Scientific Reports. 2016 Feb 15; 6: 21225.        IF:5.228

9.       Jinjian Liu#, Hongzhang Deng#, Qiang Liu, Liping Chu, Yumin Zhang, Cuihong Yang, Xuefei Zhao, Pingsheng Huang, Liandong Deng, Anjie Dong*, Jianfeng Liu*. Integrin-targeted pH-responsive micelles for enhanced anticancer efficiency in vitro and in vivo. Nanoscale. 2015 Feb 13; 7(10): 4451-60.  IF:7.76

10.   Pingsheng Huang#, Jinjian Liu#, Weiwei Wang, Yumin Zhang, Fuli Zhao, Deling Kong, Jianfeng Liu*, Anjie Dong*. Zwitterionic nanoparticles constructed from bioreducible RAFT-ROP double head agent for shell shedding triggered intracellular drug delivery. Acta Biomaterialia. 2016 Aug;40:263-72.  IF:6.008

11.   Pingsheng Huang#, Yumin Zhang#, Weiwei Wang, Junhui Zhou, Yu Sun, Jinjian Liu, Deling Kong, Jianfeng Liu*, Anjie Dong*. Co-delivery of doxorubicin and 131I by thermosensitive micellar-hydrogel for enhanced in situ synergetic chemoradiotherapy. Journal of Controlled Release. 2015 Nov 10;220(Pt A): 456-64.   IF:7.441

12.   Cuihong Yang, Liping Chu, Yumin Zhang, Yang Shi, Jinjian Liu, Qiang Liu, Saijun Fan, Zhimou Yang, Dan Ding*, Deling Kong*, Jianfeng Liu*. Dynamic biostability, biodistribution, and toxicity of L/D-peptide-based supramolecular nanofibers. ACS Applied Materials & Interfaces. 2015 Feb 4; 7(4):2735-44. IF:7.145

13.   Hongzhang Deng#, Yumin Zhang#, Xue Wang, Jianhua Zhang, Yan Cao, Jinjian Liu, Jianfeng Liu*, Liandong Deng*, Anjie Dong. Balancing the stability and drug release of polymer micelles by the coordination of dual-sensitive cleavable bonds in cross-linked core. Acta Biomaterialia. 2015 Jan;11:126-36.  IF:6.008 

14.   Jianfeng Liu, Jinjian Liu, Liping Chu, Yumin Zhang, Hongyan Xu, Deling Kong, Zhimou Yang, Cuihong Yang*, Dan Ding*. Self-assembling peptide of D-amino acids boosts selectivity and antitumor efficacy of 10-Hydroxycamptothecin.  ACS Applied Materials & Interfaces. 2014 Mar 23; 6(8):5558-65.     IF:6.723

15.   Pingsheng Huang#, Jinjian Liu#, Weiwei Wang, Chen Li, Junhui Zhou, Xue Wang, Liandong Deng, Deling Kong, Jianfeng Liu*, Anjie Dong*. Zwitterionic nanoparticles constructed with well-defined reduction-responsive shell and pH-sensitive core for "spatiotemporally pinpointed" drug delivery.​ ACS Applied Materials & Interfaces. 2014 Aug 27; 6(16):14631-43. IF:6.723

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